Intranasal Immunization with NadA of Antibodies and Cellular Immunity following Meningococci: Induction of Bactericidal Mucosal Vaccination against Serogroup B
نویسندگان
چکیده
10.1128/IAI.72.7.4052-4060.2004. 2004, 72(7):4052. DOI: Infect. Immun. Kingston H. G. Mills Rae, Alan Huett, Rino Rappuoli, Gordon Dougan and Aaron Hale, Simon Clare, Beatrice Arico, Marzia M. Giuliani, Frances Bowe, Ed C. Lavelle, Edel A. McNeela, Christine Heat-Labile Enterotoxin Escherichia coli and Mutants of Neisseria meningitidis Intranasal Immunization with NadA of Antibodies and Cellular Immunity following Meningococci: Induction of Bactericidal Mucosal Vaccination against Serogroup B
منابع مشابه
The Neisseria meningitidis macrophage infectivity potentiator protein induces cross-strain serum bactericidal activity and is a potential serogroup B vaccine candidate.
A gene encoding a 29-kDa protein from Neisseria meningitidis serogroup B strain MC58 with homology to the macrophage infectivity potentiator (MIP) protein of Legionella pneumophila was cloned and expressed in Escherichia coli, and the purified soluble recombinant protein (rMIP) was used for immunization studies. Analysis of the predicted amino acid sequences of MIP from 13 well-characterized me...
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In induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (MALT) M cells. In this study, we determined the systemic and mucosal immune responses in rabbits following intranasal immunization of tetanus toxoid TT and CpG-ODN encapsulated within PLGA nanos...
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In induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (MALT) M cells. In this study, we determined the systemic and mucosal immune responses in rabbits following intranasal immunization of tetanus toxoid TT and CpG-ODN encapsulated within PLGA nanos...
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No vaccine is available for preventing infections by serogroup B Neisseria meningitidis (MenB), which accounts for a major portion of meningococcal cases in developed countries, because of the poor immunogenicity of the capsular polysaccharide (CP) even after protein conjugation. We have previously induced anticapsular antibodies by immunization with a single chain variable fragment (scFv), whi...
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